Protective effect of polyprenols against acute liver injury in- duced by CCl4 and D-Gal

نویسندگان

  • Fang-Jie Sun
  • Jun-Feng Jia
چکیده

Objective: To study the protective effect of polyprenols on acute liver injury induced by CCl4 and D-Gal. Method: The acute liver injury model induced by 0.5% CCl4 in olive oil (10ml/kg) and D-Gal (800mg/kg, i.p.) in mice and rats respectively. 10, 40 and 160 mg/kg polyprenols was administered i.g., to study the protective effect for different doses of polyprenols, the therapeutic effect of each groups was assessed using the activities of ALT and AST in serum, and observed pathological changes of liver. Result: polyprenols can reduce significantly the increase of ALT and AST in serum and the level of liver injury induced by CCl4 and D-Gal. Conclusion: Polyprenols has the powerful protective effect on acute liver injury induced by CCl4 and D-Gal.

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تاریخ انتشار 2015